Liquen plano, estudio retrospectivo en un hospital pediátrico / Lichen planus, retrospective study in a pediatric hospital

Introducción: El liquen plano (LP) es una enfermedad inflamatoria crónica, de etiología desconocida, que puede afectar la piel, los anexos y las mucosas. Objetivo: Describir las características epidemiológicas y clínicas y el tratamiento realizado en los pacientes con diagnóstico clínico e histopatológico de LP, valorados en el Servicio de Dermatología del Hospital de Pediatría "Prof. Dr. Juan P. Garrahan" en los últimos 33 años. Diseño:Estudio descriptivo, retrospectivo y transversal. Materiales y métodos: Se revisaron las historias clínicas de los pacientes con diagnóstico histopatológico de LP atendidos en el Hospital desde agosto de 1987 hasta febrero de 2020 y se analizaron las variables epidemiológicas, clínicas y de tratamiento. Resultados: Se incluyeron datos de 26 pacientes, 18 de los cuales eran varones (69,3%). La media de edad en el momento del diagnóstico fue de 9,6 años. Presentaron la variedad de LP clásico 24 pacienes (93%). El compromiso ungueal y de la mucosa bucal se observó en 2 pacientes (7,7%). Ninguno tuvo asociación a fármacos ni a infecciones. En cuanto al tratamiento recibido, 4 pacientes (15,4%) tuvieron pérdida del seguimiento; 13 (50%) realizaron tratamiento tópico; 6 (23%), tratamiento sistémico y 3 (11,5%), tratamiento combinado. El promedio de seguimiento fue de 6 meses y se obtuvo una respuesta favorable en el 68% de los pacientes. Conclusiones: El LP es una patología de baja frecuencia en la infancia. No se encontró asociación a medicamentos ni a enfermedades infecciosas como se describe en la población adulta. Su curso es crónico y, en los pacientes que tuvieron un adecuado seguimiento, se obtuvo una buena respuesta al tratamiento indicado.

Introduction: Lichen planus (LP) is a chronic, inflammatory disease of unknown etiology, which can affect skin, adnexal tissues and mucosa. Objective: to describe the clinical, epidemiological characteristics and the treatment received by patients with clinical and histopathological diagnosis of LP, seen at the Dermatology Service of Pediatric Hospital "Prof. Dr. Juan P. Garrahan" in the last 33 years. Design: Descriptive, retrospective and cross-sectional study. Materials y methods: We reviewed the clinical history of patients with histopathological diagnosis of LP that were treated at our hospital from August 1987 to February 2020 and analysed the epidemiological, clinical and treatment variables. Results: Data of 26 patients were included in this study 18 of which are males (69.3%). The mean age of diagnosis was 9.6 years. 24 patients (93%) presented the classical type of LP. Ungual and mucosal compromise were observed in 2 patients (7.7%) and none had associations with infections or drugs. Regarding treatment, 4 patients (15.4%) did not continue follow-ups, 13 patients (50%) had topical treatment, 6 (23%) had systemic treatment and 3 patients (11.5%) received combined treatment. The average follow-up time was 6 months and 68% of patients had favorable outcome. Conclusions: LP is an uncommon pathology in children. During this study we did not find any etiologic relations with use of drugs or infectious diseases as is described in de adult population. Its course is chronic and in the patients that had a proper follow-up a good response to the indicated treatment was obtained.

Lichen planopilaris epidemiology: a retrospective study of 80 cases

AbstractBACKGROUND:Lichen planopilaris is a frequent presentation of primary cicatricial alopecia. Scalp distribution characterizes the main clinical presentations: classic lichen planopilaris, frontal fibrosing alopecia and Graham-Little Piccardi-Lassueur Syndrome (GLPLS).OBJECTIVE:Description of the clinical, dermoscopic and histopathological findings of Lichen planopilaris in public and private practices.METHOD:A retrospective observational study was performed by reviewing medical records of patients with lichen planopilaris.RESULTS:Eighty patients were included, 73 (91,25%) were female. Prototype II was seen in 53 (66,25%) patients. Classic lichen planopilaris was seen in 62,5% of the cases. Frontal fibrosing alopecia was seen in 31% of the patients and only one patient presented Graham-Little Piccardi-Lassueur Syndrome (GLPLS). Scalp lesions were scattered throughout the scalp in 47 (58,75%) of the patients, while 24 (30%) presented mainly central scalp lesions, 29 (36,25%) presented marginal lesions and only 4 (5%) patents had vertex lesions.CONCLUSIONS:Clinical presentation of Lichen planopilaris varies. To recognize the heterogeneity of the clinical appearance in lichen planopilaris is important for differential diagnosis.

Frontal fibrosing alopecia and lichen planopilaris in HLA-identical mother and daughter.

Frontal fi brosing alopecia (FFA) is a lymphocyte-mediated scarring alopecia thought to be a variant of lichen planopilaris (LPP). We present a 67-year-old woman with frontal fi brosing alopecia whose daughter was diagnosed to have lichen planopilaris. Both patients had identical human leukocyte antigen (HLA) D types, supporting a phenotypical relationship between the two clinical entities. Interestingly, our patient also had of autoimmune chronic atrophic gastritis, a previously unreported association.

Frequency of lichen planus in patients with hepatitis C virus infection

Lichen planus is a chronic inflammatory dermatosis of unknown etiology. Its association with liver diseases, particularly hepatitis C virus [HCV], has been widely approached since 1990 when serology for detection of HCV became available. The aim of the present study was to determine the frequency of lichen planus in patients infected with HCV attending the viral hepatitis clinic at Aljamahiriya hospital, Benghazi. Two hundred patients of hepatitis C infection and 100 individuals, served as a control group, were enrolled in this study and were assessed for the presence of Lichen planus. In addition the route of HCV transmission, viral genotype and duration of HCV infection were also assessed. Out of two hundred patients, 104 were females and 96 were males, with age range 15-80 years. One case of oral Lichen planus [0.5%] and one case of cutaneous Lichen planus [0.5%] were found compared to two cases [2%] and one case [1%] of cutaneous and oral Lichen planus found in the control group, respectively [p > 0.05]. The diagnosis of Lichen planus was confirmed with histopathology findings in all cases. The findings of the present study indicate that there is no association between oral and cutaneous Lichen planus and hepatitis C infection. Further studies are needed in a larger number of patients to determine the association betueen HCV virus infected patients and Lichen planus

Can deram be a cause of oral lichen planus?

To study the relationship between oral lichen planus [LP] and the habit of chewing deram. A clinically based controlled observational study including a total of 176 women who used to chew deram and 200 women who never used deram, who consulted the Dermatology Department of Basrah Teaching Hospital, and a private clinic, Barsah, Iraq during the period from February 2005 to July 2007. The study showed that the incidence of oral LP is greater among 176 deram chewers [23.3%] in comparison with 200 women who never use deram [1.5%], particularly among those with frequent [51.2%] and prolonged [65.8%] chewing of deram. Oral lesions, were mostly asymptomatic [80.5%] and predominantly of reticulate pattern [87.9%]. Avoidance of deram chewing induced marked or complete improvement of the oral lesions in 56.3% of cases even without treatment within a 3 month follow up period. Pathological examination showed features similar to classical LP. Deram chewing should be considered as a possible cause of oral LP, particularly among frequent and prolonged chewers

Dermatosis liquenoides / Lichenoid dermatoses

Las Dermatosis Liquenoides son un grupo de enfermedades frecuentes en Dermatología. La palabra liquen produce confusión a los dermatólogos, pues es utilizada indistintamente para definir un patrón histopatológico de infiltrado linfocítico en banda en la membrana basal, así como también un patrón clínico de pápulas violáceas aplanadas y brillantes. Considerando su frecuencia, es conveniente que los dermatólogos se encuentren bien familiarizados con estos conceptos en orden a realizar diagnósticos precisos y así otorgar tratamientos adecuados a estos pacientes.

Lichenoid dermatoses are a group of diseases frequently seen in dermatology. The word lichen tends to confuse dermatologists because this term describes a histopathological pattern characterized by a band-like lymphocytic infiltrate in the basal membrane, as well as a clinical pattern of flat, violet, shiny papules. Given the high number of patients suffering from this disorder, it is advisable for dermatologists to be well familiarized with these concepts in order to give an accurate diagnosis and suitable treatment.

Association of lichen planus with hepatitis C virus infection

An association between HCV infection and lichen planus is uncertain because the prevalence of HCV infection in patients with lichen planus varies considerably from one geographic area to another. The purpose of this study was to determine the frequency of anti-HCV antibodies and its association with various clinical types of lichen planus in Mekkah, Saudi Arabia. A total of 114 cases of lichen planus were selected for the study. These were divided into four categories, including patients with skin lesions, skin and oral lesions, and oral or genital lesions alone. The sera of these patients were tested for HCV antibodies by means of a third-generation ELISA and serum levels of aspartate aminotransferase [AST] and alanine aminotransferase [ALT] were simultaneously determined. A group of 65 volunteers served as a control group. Of the 114 patients with lichen planus, 30 had HCV antibodies [26.3%]. In the 65 control group subjects anti-HCV antibodies were observed in 3 volunteers [4.6%]. There was a significant difference between the two groups [P<0.0001]. The ALT was raised in 22 patients and the AST level was elevated in 14 of the 114 cases of lichen planus. In the control group, the AST level was raised in 3 of the 65 controls while 2 had an elevated ALT level. The number of patients with an abnormal transaminase level also significantly differed in the two groups. A high prevalence of HCV infection was detected in patients with lichen planus. These results support a possible relationship between lichen planus and hepatitis C

Liquen plano e infección crónica por virus hepatitis C / Lichen planus and chronic infection by hepatitis C virus

El liquen plano afecta al 0,3 por ciento a 0,8 por ciento de la población general. La seroprevalencia para virus hepatitis C (VHC) en donantes de sangre en Chile es de 0,3 por ciento a 0,6 por ciento. Varios autores han comunicado una mayor prevalencia de la infección crónica por VHC en pacientes con LP, pero esta asociación es aún controversial. El objetivo de este estudio fue establecer si existe una asociación entre LP y la infección por VHC en nuestro pais. Pacientes y método. Se examinaron piel y mucosa de 59 pacientes portadores de VHC. Paralelamente, se estudió la serología para VHC (ELISA) en 19 pacientes con LP. Resultados. El grupo de pacientes con hepatitis C exhibió un alto número de patologías cutáneas y mucosas. Se confirmó un caso de LP en los 59 pacientes con VHC (1,7 por ciento). La serología para VHC fue positiva en un paciente con LP (5,3 por ciento). Conclusiones. La infección crónica por VHC se asocia a muchas patología cutáneas. Nuestros resultados no son concluyentes respecto a una asociación entre la infección crónica por VHC y el LP en nuestros pacientes

Familial actinic lichen planus: case reports in two brothers

We report two cases of a 17- and 19-year-old brothers from Rasht [North of Iran], who presented with actinic lichen planus lesions. The younger brother had typical annular patches on his forehead and neck and violaceous papules on his neck. The second brother presented with pigmented melasma-like lesions on his face. Histopathologic studies revealed lichen planus-like eruptions. Many reports describe the tendency of familial lichen planus [LP] developing at an early age and to becoming severe or chronic, and having widespread atypical manifestations. Our report probably is the first, which describes familial occurrence of actinic LP and adds further evidence to the possible role of genetic factors in triggering and determining different types of LP other than the disease itself

Líquen plano: estudo clínico-epidemiológico de 160 casos / Lichen planus: clinical epidemiologic study of 160 cases

Com o objetivo de estudar o comportamento clínico-epidemiológico e comparar os resultados obtidos com a literatura médica mundial, foi realizada uma análise retrospectiva de 160 casos de líquen plano, selecionado entre 201.723 pacientes portadores de dermatoses diversas, atendidos no ambulatório de Dermatologia do Hospital Universitário Antônio Pedro (HUAP). Niterói, Rio de Janeiro, entre 1973 e 1988 (16 anos). A amostra foi representada por 46 pacientes do sexo masculino (28,75//) e 114 do sexo feminino (71,25//), sendo 86 brancos(53,75//), 27 negros (16,87//) e 47 pardos (29,35//), com idades variando de quatro meses a 83 anos